The present study focuses on the formulation and evaluation of a curcumin - loaded sodium alginate gel intended for wound healing applications. Curcumin, a natural polyphenolic compound derived from Curcuma longa, exhibits potent anti-inflammatory, antioxidant and antimicrobial properties, making it a promising candidate for wound treatment. However, its poor aqueous solubility and limited bioavailability hinder its clinical utility. To overcome these limitations, a sodium alginate - based gel system was developed to enhance curcumin delivery and sustain its release at the wound site. The gels were prepared using sodium alginate and cross-linked with calcium chloride to achieve optimal consistency and stability. The prepared formulations were subjected to a series of physicochemical evaluations, including pH, viscosity, spreadability and drug content analysis. In-vitro drug release studies were conducted to assess the release profile of curcumin from the gel matrix. The prepared formulation demonstrated desirable physicochemical characteristics and sustained curcumin release. These findings suggest that the curcumin-loaded sodium alginate gel is a promising topical delivery system for effective wound healing therapy.
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